Paula Badosa defeated Victoria Azarenka in the final, 7–6(7–5), 2–6, 7–6(7–2), to win the women's singles tennis title at the 2021 Indian Wells Masters. At three hours and four minutes, the final was the longest women's final contested at Indian Wells. By winning the title, Badosa became the first Spanish woman to win the tournament. This was her first WTA 1000 title and her second career WTA singles title overall. Azarenka was aiming to become the first woman to win the title at Indian Wells three times.