The 2018 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2018 NCAA Division I FBS football season. The Golden Eagles played their home games at the M. M. Roberts Stadium in Hattiesburg, Mississippi and competed in the West Division of Conference USA (C–USA). They were led by third-year head coach Jay Hopson. They finished the season 6–5, 5–3 in C-USA play to finish in a three-way tie for second in the West Division. Despite being bowl eligible, they were not invited to a bowl game.