The 2016 Wilson Security Sandown 500 was a motor racing event for Supercars, held from 16 to 18 September 2016 at the Sandown Raceway in Melbourne, Victoria, Australia and consisted of one race of 445 kilometres in length. It was the tenth event of fourteen in the 2016 International V8 Supercars Championship and hosted Race 20 of the season. It was also the first event of the 2016 Enduro Cup. The event was the 46th running of the Sandown 500.