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The 1981 Avon Championships of Detroit was a women's tennis tournament played on indoor carpet courts at the Cobo Hall & Arena in Detroit, Michigan in the United States that was part of the 1981 Avon Championships circuit. It was the tenth edition of the tournament and was held from February 2 through February 8, 1981. Unseeded Leslie Allen won the singles title and earned $24,000 first-prize money.