The 1959 VFL Grand Final was an Australian rules football game contested between the Melbourne Football Club and Essendon Football Club, held at the Melbourne Cricket Ground on 20 September 1959. It was the 62nd annual Grand Final of the Victorian Football League, staged to determine the premiers for the 1959 VFL season. The match, attended by 103,506 spectators, was won by Melbourne by 37 points, marking that club's tenth premiership victory.