The 1941 Pittsburgh Panthers football team was an American football team that represented the University of Pittsburgh as an independent during the 1941 college football season. In their third year under head coach Charley Bowser, the Panthers compiled a 3–6 record and were outscored by a total of 171 to 82. Guard Ralph Fife was selected as a first-team All-American by the Associated Press (AP). Fife was also selected by the AP as a first-team player on the 1941 All-Eastern football team. Halfback Edgar Jones was named to the second team on the All-Eastern team.