The 1900 Clemson Tigers football team represented Clemson Agricultural College—now known as Clemson University–during the 1900 Southern Intercollegiate Athletic Association football season. Under first year head coach John Heisman, the team posted a 6–0 record and Southern Intercollegiate Athletic Association (SIAA) championship. The Tigers outscored their opponents 222–10; the 64–0 win over Davidson on opening day was then the largest score ever made in the South and the season's only home game. The only close game was with the South Atlantic school VPI.