The Wayekiye family was a Nubian priestly family that was influential in the Dodekaschoinos between Upper Egypt and Nubia in the second and third centuries CE, named after two of its members. They are attested by mostly Demotic temple inscriptions. Although the Roman government directed the taxes of the Dodekaschoinos to the Egyptian temple cults of Isis of Philae and Thoth of Dakka, most of the population was not ethnically Egyptian but Nubian, as were local elites like the Wayekiye. The family eventually came to serve the Nubian Kushite court of Meroë and may have acted as a "vehicle for the penetration of Meroitic royal authority" into the area, culminating in Kush's annexation of the area in the third century.