Spartanburg is a city in and the seat of Spartanburg County, South Carolina, United States. The city of Spartanburg has a municipal population of 38,732 as of the 2020 Census, making it the 11th-largest city in the state. For a time, the Office of Management and Budget (OMB) grouped Spartanburg and Union Counties together as the Spartanburg metropolitan statistical area, but as of 2018,the OMB defines only Spartanburg County as the Spartanburg MSA.