Simon Paulli (6 April 1603 – 25 April 1680), was a Danish physician and naturalist. He was a professor of anatomy, surgery and botany at the University of Copenhagen. The genus Paullinia is named after him. Paulli was the first to Frederick III of Denmark, and made valuable contributions to anatomy and botany. He authored and published several treatises in medicine and botany, notably, Quadripartitum Botanicum. He was also a driving force between the establishment of the Domus Anatomica, the first anatomical theatre in Copenhagen.