Patizeithes (Greek: Πατιζείθης, romanized: Pathizeíthēs) was a Persian magus (priest) who flourished in the second half of the 6th century BC. According to Herodotus, he persuaded his brother Smerdis (Gaumata) in 521 BC to rebel against Cambyses II (r. 530–522 BC), who at the time ruled as King of Kings of the Achaemenid Persian Empire. Herodotus states that Patizeithes was eventually killed by Cambyses's successor Darius (later "the Great") (r. 522–486 BC).