M-53 is a north–south state trunkline highway in the US state of Michigan that connects Detroit to The Thumb region. The highway starts in Detroit at a connection with M-3 and ends in Port Austin, Michigan at M-25. In between, the trunkline passes through the northern suburbs of Metro Detroit, connects to freeways like Interstate 69 (I-69) and provides access to rural farmland. In Macomb County, M-53 follows the Christopher Columbus Freeway and POW/MIA Memorial Freeway, while the remainder of the highway is known as Van Dyke Avenue in the metro area or Van Dyke Road elsewhere. The highway has also been named the Earle Memorial Highway for one of the pioneers of the Good Roads Movement and Michigan's highway system.