Frank Crenshaw Millspaugh (January 14, 1872 – July 8, 1947) was a United States Representative from Missouri. Born in Shawneetown, Illinois, Millspaugh attended public schools. He entered the grain commission business in New Orleans, Louisiana, in 1891. He moved to Chicago in 1892, to St. Louis, Missouri, in 1894 and to Canton, Missouri, in 1896 and continued the grain shipping business. He engaged in banking 1900-1921. He served as delegate to the Republican State convention in 1912. He served as mayor of Canton, Missouri from 1915 to 1919.