Wynne Senior High School, known as Wynne High School, is a public secondary school for students in grades nine through twelve located in Wynne, Arkansas, United States. It is one of two public high schools in Cross County and the sole high school administered by the Wynne School District. In addition to Wynne it also serves Parkin, since the former Parkin School District merged into the Wynne district on September 7, 2005.