William McAndrew (April 29, 1887 – February 11, 1943) was an American football, basketball, and baseball coach and college athletics administrator. He served two stints at the head football coach at Southern Illinois University Carbondale, from 1913 to 1916 and then returning from 1921 to 1938, compiling a record of 83–79–20 in 22 seasons. His 83 wins are the most of any head coach in the history of the Southern Illinois Salukis football program. McAndrew was also the head basketball coach at Southern Illinois from 1913 to 1943, tallying a mark of 309–221, and the school head baseball coach from 1921 to 1924.