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Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.

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  • Wee1 (cs)
  • Wee1 (fr)
  • Wee1 (it)
  • Wee1 (en)
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  • Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. (en)
  • Wee1 è una chinasi inibitoria che interviene nell'attivazione del complesso Cdk1-ciclina B, MPF, tramite fosforilazione durante il checkpoint G2/M. (it)
  • Wee1 je eukaryotická proteinkináza, která se podílí na řízení buněčného cyklu. U kvasinky fosforyluje tyrosin v proteinu cdc2, u lidí je schopná na odpovídajícím proteinu (Cdk1) fosforylovat i threonin. Kinázová aktivita se soustřeďuje do střechy aktivního místa zmíněných enzymů. (cs)
  • Wee1 est une de la famille Serine/thréonine kinase dont le substrat est la cycline M-CDK. Elle a un rôle dans la division cellulaire par l'intermédiaire de l'horloge circadienne, celle ci étant un système qui permet la régulation de nombreux processus biologiques vitaux. L’altération de cette horloge est liée à de nombreuses conditions pathologiques telles que le cancer, ce qui suggère l’importance d’une régulation circadienne du cycle de division cellulaire. La compréhension de ce cycle est primordiale pour l’étude de la prolifération cellulaire dans le corps humain. (fr)
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  • Wee1 (en)
  • human WEE1 homolog (S. pombe) (en)
  • human WEE1 homolog 2 (S. pombe) (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Cellcycleprotein_Wee1.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/PBB_Protein_WEE1_image.jpg
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