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About: Uroguanylin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatPeptides, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Amide114724264yago:Chemical114806838yago:Compound114818238yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:Peptide114743046yago:PhysicalEntity100001930yago:Relation100031921chemical compoundproteinyago:Substance100019613yago:WikicatPeptides New Facet based on Instances of this Class

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH. In humans, the uroguanylin peptide is encoded by the GUCA2B gene. Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.