The second USS Cyane was a sloop-of-war in the United States Navy during the Mexican–American War. Cyane was launched 2 December 1837 by Boston Navy Yard. She was commissioned in May 1838, Commander John Percival in command. In August 1858 Cyane stood out for the Pacific, joining the Pacific Squadron. In 1863, during the Civil War, the Cyane prevented the sloop J. M. Chapman from being used as a Confederate privateer when her armed boarding party took control of the ship as it was preparing to leave San Francisco.