U.S. Route 441 (US 441) is a north–south United States Highway that runs from Miami, Florida to Rocky Top, Tennessee. In the U.S. state of North Carolina, US 441 travels for 64.5 miles (103.8 km) from the Georgia state line near Dillard, Georgia to the Tennessee state line in the Great Smoky Mountains National Park. US 441 is a primary route connecting the cities of Franklin, Sylva, and Cherokee in western North Carolina. The highway runs concurrently with other U.S. highways for much of its routing in North Carolina including US 23 from the Georgia state line to Dillsboro, US 64 in Franklin, US 74 from Dillsboro to near , and US 19 in Cherokee. US 441 has two business routes in North Carolina, in Franklin and Cherokee.