U.S. Route 275 (US 275) is a north–south United States highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The highway's northern terminus is in O'Neill, Nebraska, at an intersection with U.S. Highway 20 and U.S. Highway 281. Its southern terminus is near Rock Port, Missouri, at an intersection with U.S. Highway 136.