U.S. Route 15 (US 15) is a north–south U.S. Highway running from Walterboro, South Carolina to Painted Post, New York. In the U.S. state of North Carolina the highway runs for 159 miles (256 km) from the South Carolina state line to the south of Laurinburg, North Carolina to the Virginia state line north of Bullock, North Carolina. US 15 travels in concurrency with U.S. Route 501 for 106 miles (171 km) between Laurinburg and Durham.