About: Trans-activation response element (TAR)

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The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter. Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim.

Attributes	Values
rdf:type	yago:WikicatCis-regulatoryRNAElements yago:WikicatNucleicAcids yago:Abstraction100002137 yago:Chemical114806838 yago:Cognition100023271 yago:Component105868954 yago:Compound114818238 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:NucleicAcid114964129 yago:OrganicCompound114727670 yago:Part105867413 yago:Part113809207 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:Relation100031921 military unit yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	Trans-activation Response Element (de) Trans-activation response element (TAR) (en)
rdfs:comment	Das Trans-activation response element ist ein Teil des genetischen Codes von HI-Viren. Das TAR-Element hat zwei Funktionen.Zum einen dient es als Erkennungs-Region für das virale Tat-Protein, das die Übersetzung der Virusbausteine reguliert. Zum anderen dient es als Vorläufer von Mikro-RNA, die Einfluss auf die Regulation der Wirtsproteine nimmt. Vor allen Dingen wird die Apoptose der befallenen Zellen gehemmt. (de) The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter. Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim. (en)
name	Trans-activation response element (en)
foaf:depiction
dct:subject	MicroRNA Cis-regulatory RNA elements
Wikipage page ID	11422351 (xsd:integer)
Wikipage revision ID	1120387865 (xsd:integer)
Link from a Wikipage to another Wikipage	BCL2L11 MicroRNA MicroRNA Cyclin-dependent kinase 9 JC virus Gene Apoptosis Tat (HIV) HIV Cis-regulatory RNA elements ERCC1 Stem-loop Cis-regulatory element IER3 Sequence conservation Long terminal repeat Virus Promotor (biology) Secondary structure Downregulation
Link from a Wikipage to an external page	https://archive.today/20121223091838/http:/microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl%3Facc=MI0007073
sameAs	Trans-activation response element (TAR) Trans-activation response element (TAR) Trans-activation response element (TAR) Trans-activation response element (TAR) Trans-activation response element (TAR)
Tax domain	Viruses (en)
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:GO dbt:SO dbt:Infobox_rfam dbt:Molecular-cell-biology-stub dbt:Rfam
thumbnail	wiki-commons:Special:FilePath/RF00250.jpg?width=300
AltSymbols	TAR (en)
caption	Predicted secondary structure and sequence conservation of mir-TAR (en)
id	RF00250 (en)
symbol	mir-TAR (en)
has abstract	Das Trans-activation response element ist ein Teil des genetischen Codes von HI-Viren. Das TAR-Element hat zwei Funktionen.Zum einen dient es als Erkennungs-Region für das virale Tat-Protein, das die Übersetzung der Virusbausteine reguliert. Zum anderen dient es als Vorläufer von Mikro-RNA, die Einfluss auf die Regulation der Wirtsproteine nimmt. Vor allen Dingen wird die Apoptose der befallenen Zellen gehemmt. (de) The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter. Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3, CDK9, and Bim. Human polyomavirus 2 (JC virus) contains a TAR-homologous sequence in its late promoter that is responsive to HIV-1 derived Tat. (en)
Rfam	RF00250 (en)
RNA type	MicroRNA Gene
gold:hypernym	Element
prov:wasDerivedFrom	wikipedia-en:Trans-activation_response_element_(TAR)?oldid=1120387865&ns=0
page length (characters) of wiki page	5506 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Trans-activation_response_element_(TAR)
is Link from a Wikipage to another Wikipage of	Aptamer Rev-ErbA beta Trans-activation response element HIV ERCC1 TAR DNA-binding protein 43 Structure and genome of HIV
is Wikipage redirect of	Trans-activation response element
is foaf:primaryTopic of	wikipedia-en:Trans-activation_response_element_(TAR)

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