On April 21–24, 1968, a deadly tornado outbreak struck portions of the Midwestern United States, primarily along the Ohio River Valley. The worst tornado was an F5 that struck portions of Southeastern Ohio from Wheelersburg to Gallipolis, just north of the Ohio–Kentucky state line, killing seven people and injuring at least 93. Another long-tracked violent tornado killed six people, injured 364 others, and produced possible F5 damage as it tracked along the Ohio River. At least one other violent tornado caused an additional fatality and 33 injuries in Ohio. In the end, at least 26 tornadoes touched down, leaving 14 dead, including five in Kentucky and nine in Ohio.