"The dose makes the poison" (Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." This is often condensed to: "The dose makes the poison" or in Latin, "Sola dosis facit venenum". It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration (i.e., dose).
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| - Dosis membuat sesuatu menjadi racun (in)
- The dose makes the poison (en)
- 抛开剂量谈毒性就是耍流氓 (zh)
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| - 剂量成毒药（拉丁語：sola dosis facit venenum），中文俗语：抛开剂量谈毒性就是耍流氓，是一个谚语，意在表明一个毒理学的基本原理：“所有物质都是毒药，并没有无毒的物质，只是因为剂量导致了毒性，不能说明该物质有毒。”这句话通常缩写为：“剂量成毒药”。在简体中文网络用语中，它通常被表述为“抛开剂量谈毒性就是耍流氓”。这也就意味着，一个物质能产生有害影响，只是因为它在受影响的生物系统内达到了足够的浓度（即“剂量”）。 (zh)
- "Dosis membuat sesuatu menjadi racun" (bahasa Latin: sola dosis facit venenum) adalah sebuah pepatah yang menjabarkan asas dasar dalam ilmu toksikologi. Pepatah ini disampaikan oleh Bapak Toksikologi Paracelsus: "Segala sesuatunya adalah racun, dan tidak ada yang tanpa racun, hanya dosis yang membuat sesuatu menjadi bukan racun." Dalam kata lain, suatu substansi baru akan menimbulkan efek racun jika dosisnya sudah cukup tinggi. (in)
- "The dose makes the poison" (Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." This is often condensed to: "The dose makes the poison" or in Latin, "Sola dosis facit venenum". It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration (i.e., dose). (en)
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| - "Dosis membuat sesuatu menjadi racun" (bahasa Latin: sola dosis facit venenum) adalah sebuah pepatah yang menjabarkan asas dasar dalam ilmu toksikologi. Pepatah ini disampaikan oleh Bapak Toksikologi Paracelsus: "Segala sesuatunya adalah racun, dan tidak ada yang tanpa racun, hanya dosis yang membuat sesuatu menjadi bukan racun." Dalam kata lain, suatu substansi baru akan menimbulkan efek racun jika dosisnya sudah cukup tinggi. Asas ini didasarkan pada temuan bahwa semua bahan kimia (termasuk air dan oksigen) dapat mengakibatkan efek racun jika dosisnya terlalu besar. Temuan ini juga menjadi dasar penetapan standar konsentrasi minimal untuk berbagai kontaminan pada makanan, minuman, dan lingkungan. Namun, bahan kimia tidak selalu mengakibatkan efek akut dalam jangka pendek. Ada pula kontaminan dengan dosis rendah yang dapat mengakibatkan efek kronis jika terpapar dalam jangka panjang. Akibatnya, terdapat standar kesehatan yang mungkin terlalu ketat atau lemah. (in)
- "The dose makes the poison" (Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." This is often condensed to: "The dose makes the poison" or in Latin, "Sola dosis facit venenum". It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration (i.e., dose). The principle relies on the finding that all chemicals—even water and oxygen—can be toxic if too much is eaten, drunk, or absorbed. "The toxicity of any particular chemical depends on many factors, including the extent to which it enters an individual’s body." This finding also provides the basis for public health standards, which specify maximum acceptable concentrations of various contaminants in food, public drinking water, and the environment. However, there is no linear relationship and chemical toxicity is more complex than merely the acute effects caused by short-term exposure. Relatively low doses of contaminants in water, food, and environment can already have significant chronic effects if there is long-term exposure. Generally the effects of different doses can be very different at different levels (not only bigger and smaller impacts depending on dose). (en)
- 剂量成毒药（拉丁語：sola dosis facit venenum），中文俗语：抛开剂量谈毒性就是耍流氓，是一个谚语，意在表明一个毒理学的基本原理：“所有物质都是毒药，并没有无毒的物质，只是因为剂量导致了毒性，不能说明该物质有毒。”这句话通常缩写为：“剂量成毒药”。在简体中文网络用语中，它通常被表述为“抛开剂量谈毒性就是耍流氓”。这也就意味着，一个物质能产生有害影响，只是因为它在受影响的生物系统内达到了足够的浓度（即“剂量”）。 (zh)
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