• Facets (new session)
• Description
• Metadata
• Settings
  • Rule: asEquivalentb3sb3sifpdbprdf-labelfacetshttp://dbpedia.org/resource/inference/rules/dbpedia#http://dbpedia.org/resource/inference/rules/opencyc#http://dbpedia.org/resource/inference/rules/umbel#http://dbpedia.org/resource/inference/rules/yago#http://dbpedia.org/schema/property_rules#http://www.ontologyportal.org/inference/rules/SUMO#http://www.ontologyportal.org/inference/rules/WordNet#http://www.w3.org/2002/07/owl#ldpoplwebskos-transvirtpivot-rulesvirtrdf-labelNone
    
  • Inverse Functional Properties: Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects
  • "Same As": Disabled (fastest) Apply to subjects only Apply to objects only Apply to both subjects and objects (recommended) Apply to subjects, objects and predicates (not recommended on big datasets) Apply to predicates only (special use cases only)

About: Thapsigargin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Matter100020827, within Data Space : dbpedia.org associated with source document(s)

Type: Thingyago:PhysicalEntity100001930yago:Substance100020090yago:WikicatHydrolaseInhibitorsdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatDrugschemical compoundyago:Agent114778436yago:CausalAgent100007347yago:Drug103247620yago:Inhibitor114724436yago:Matter100020827 New Facet based on Instances of this Class

Thapsigargin is non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a sesquiterpene lactone, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells. Thapsigargin treatment and the resulting ER calcium depletion inhibits autophagy independent of the UPR response. Thapsigargin is useful in experimentation examining the impacts of increasing cytosolic calcium concentrations and ER calcium depletion.