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Tedizolid (formerly torezolid, trade name Sivextro), is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. It was developed by Cubist Pharmaceuticals, following acquisition of Trius Therapeutics (originator: Dong-A Pharmaceuticals), and is marketed for the treatment of acute bacterial skin and skin structure infections (also known as complicated skin and skin-structure infections (cSSSIs)). Tedizolid was approved for medical use in the United States in June 2014, and for medical use in the European Union in March 2015.

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  • Tedizolid (de)
  • Tédizolide (fr)
  • Тедизолид (ru)
  • Tedizolid (en)
  • Тедизолід (uk)
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  • Tedizolid (Handelsname Sivextro) ist neben Linezolid ein Reserveantibiotikum der Gruppe der Oxazolidinone und wird zur Behandlung von Infektionen der Haut und des Gewebes unter der Haut durch multiresistente Bakterien wie MRSA eingesetzt. Im Vergleich zu Linezolid hat es eine vier- bis sechzehnfache Wirkung gegen Staphylokokken und Enterokokken. Die eingesetzte Dosis ist im Regelfall 200 mg/Tag. Tedizolid wurde von Trius Therapeutics bis zur Marktreife entwickelt und folgend von Cubist Pharmaceuticals übernommen. Das Antibiotikum wurde 2015 von der Europäischen Kommission zugelassen. Die Bioverfügbarkeit von Tedizolid beträgt 91 %. Die biologische Halbwertszeit liegt bei 12 Stunden. (de)
  • Le tédizolide est un antibiotique de la classe des oxazolidinones. (fr)
  • Тедизолид — антибиотик класса оксазолидинонов для лечения острых бактериальных инфекций кожи и мягких тканей. Одобрен для применения: США (2014). С 1 января включен в перечень ЖНВЛП России. (ru)
  • Тедизолід (раніше торезолід) — синтетичний антибіотик з групи для перорального та парентерального застосування. (uk)
  • Tedizolid (formerly torezolid, trade name Sivextro), is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. It was developed by Cubist Pharmaceuticals, following acquisition of Trius Therapeutics (originator: Dong-A Pharmaceuticals), and is marketed for the treatment of acute bacterial skin and skin structure infections (also known as complicated skin and skin-structure infections (cSSSIs)). Tedizolid was approved for medical use in the United States in June 2014, and for medical use in the European Union in March 2015. (en)
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  • XX11 (en)
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