| rdfs:comment
| - TBA価（ティービーエーか）とは、油脂の変質の指標となる数値のひとつ。 (ja)
- Οι ουσίες που αντιδρούν με το θειοβαρβιτουρικό οξύ (Thiobarbituric acid reactive substances, TBARS) σχηματίζονται ως παραπροϊόντα της (δηλαδή ως προϊόντα διάσπασης των λιπών) που μπορεί να ανιχνευθεί με την μέθοδο TBARS, χρησιμοποιώντας θειοβαρβιτουρικό οξύ ως αντιδραστήριο. Επειδή οι (ROS) έχουν εξαιρετικά σύντομο χρόνο ημιζωής, είναι δύσκολο να μετρηθούν άμεσα. Αντίθετα, αυτό που μπορεί να μετρηθεί είναι τα διάφορα προϊόντα της ζημιάς που προκαλείται από το οξειδωτικό στρες, όπως οι TBARS. (el)
- Thiobarbituric acid reactive substances (TBARS) are formed as a byproduct of lipid peroxidation (i.e. as degradation products of fats) which can be detected by the TBARS assay using thiobarbituric acid as a reagent. TBARS can be upregulated, for example, by heart attack or by certain kinds of stroke. Because reactive oxygen species (ROS) have extremely short half-lives, they are difficult to measure directly. Instead, what can be measured are several products of the damage produced by oxidative stress, such as TBARS. (en)
- As substâncias reativas ao ácido tiobarbitúrico - TBARS (do inglês: Thiobarbituric acid reactive substances) - são formadas como um subproduto da peroxidação lipídica (isto é, como produtos de degradação de gorduras) que podem ser detectadas pelo ensaio TBARS usando ácido tiobarbitúrico como um reagente. Devido ao fato que as espécies reativas de oxigênio têm meia-vida extremamente curta, elas são difíceis de medir diretamente. Em vez disso, o que pode ser medido são os vários produtos dos danos produzidos pelo stress oxidativo, tais como as TBARS. (pt)
|
| has abstract
| - Οι ουσίες που αντιδρούν με το θειοβαρβιτουρικό οξύ (Thiobarbituric acid reactive substances, TBARS) σχηματίζονται ως παραπροϊόντα της (δηλαδή ως προϊόντα διάσπασης των λιπών) που μπορεί να ανιχνευθεί με την μέθοδο TBARS, χρησιμοποιώντας θειοβαρβιτουρικό οξύ ως αντιδραστήριο. Επειδή οι (ROS) έχουν εξαιρετικά σύντομο χρόνο ημιζωής, είναι δύσκολο να μετρηθούν άμεσα. Αντίθετα, αυτό που μπορεί να μετρηθεί είναι τα διάφορα προϊόντα της ζημιάς που προκαλείται από το οξειδωτικό στρες, όπως οι TBARS. Ο προσδιορισμός των TBARS μετρά την (μαλονδιαλδεϋδη, MDA) που περιέχεται στο δείγμα, καθώς και την MDA που δημιουργείται από τις κάτω από τις υδρολυτικές συνθήκες της αντίδρασης. Η MDA είναι ένα από τα πολλά χαμηλού μοριακού βάρους προϊόντα που σχηματίζονται μέσω της αποσύνθεσης συγκεκριμένων προϊόντων της υπεροξείδωσης των λιπιδίων. Η μέτρηση της MDA είναι λοιπόν μία φωτομετρική μέθοδος για τον προσδιορισμό του βαθμού υπεροξείδωσης των λιπιδίων. Ωστόσο, ορισμένα μόνο προϊόντα της υπεροξείδωσης των λιπιδίων παράγουν MDA και, επιπλέον, η MDA δεν είναι ούτε το μοναδικό τελικό προϊόν της σύνθεσης και αποσύνθεσης υπεροξειδίων των λιπιδίων, ούτε μια ουσία που παράγεται αποκλειστικά μέσω της υπεροξείδωσης των λιπιδίων. Αυτές και άλλες παραδοχές με βάση και την εκτεταμένη βιβλιογραφία σχετικά με την MDA, την δραστικότητα του θειοβαρβιτουρικού και την οξειδωτική αποικοδόμηση των λιπιδίων υποστηρίζουν το συμπέρασμα ότι ο προσδιορισμός της MDA και η μέθοδος του θειοβαρβιτουρικού μπορεί να αποτελέσει, στην καλύτερη περίπτωση, μία περιορισμένη και σχετικά εμπειρική μέθοδο για την μελέτη της πολύπλοκης διαδικασίας της υπεροξείδωσης των λιπιδίων. Η χρησιμοποίηση της ανάλυσης της MDA και/ή η μέθοδος του θειοβαρβιτουρικού και ερμηνεία της περιεχομένης σε δεδομένο δείγμα MDA απαιτούν προσοχή, διακριτικότητα και, ιδιαίτερα σε βιολογικά συστήματα, συσχετικά δεδομένα από άλλους δείκτες σχηματισμού και αποσύνθεσης υπεροξειδίων των λιπιδίων. (el)
- Thiobarbituric acid reactive substances (TBARS) are formed as a byproduct of lipid peroxidation (i.e. as degradation products of fats) which can be detected by the TBARS assay using thiobarbituric acid as a reagent. TBARS can be upregulated, for example, by heart attack or by certain kinds of stroke. Because reactive oxygen species (ROS) have extremely short half-lives, they are difficult to measure directly. Instead, what can be measured are several products of the damage produced by oxidative stress, such as TBARS. Assay of TBARS measures malondialdehyde (MDA) present in the sample, as well as malondialdehyde generated from lipid hydroperoxides by the hydrolytic conditions of the reaction. MDA is one of several low-molecular-weight end products formed via the decomposition of certain primary and secondary lipid peroxidation products. However, only certain lipid peroxidation products generate MDA, and MDA is neither the sole end product of fatty peroxide formation and decomposition, nor a substance generated exclusively through lipid peroxidation. These and other considerations from the extensive literature on MDA, TBA reactivity, and oxidative lipid degradation support the conclusion that MDA determination and the TBA test can offer, at best, a narrow and somewhat empirical window on the complex process of lipid peroxidation. Use of MDA analysis and/or the TBA test and interpretation of sample MDA content and TBA test response in studies of lipid peroxidation require caution, discretion, and (especially in biological systems) correlative data from other indices of fatty peroxide formation and decomposition. Malondialdehyde reacts with both barbiturate and thiobarbiturate, and the end-product of the TBARS assay is almost identical to the end product of the pyridine-barbiturate cyanide assay. This suggests that some cyanide poisoning cases that relied on the pyridine-barbiturate diagnostic could be false positives with elevated blood malondialdehyde, and no cyanide present at all. The cases of Urooj Khan, lottery winner of Chicago, and Autumn Klein, doctor of Pittsburgh, both fit these characteristics, since neither patient exhibited cyanide poisoning symptoms, yet both appeared to have suffered heart attacks, with Urooj Khan's blocked arteries noted at autopsy and Autumn Klein's evidence for heart abnormalities noted at trial and as a central part of her husband's conviction appeal. (en)
- TBA価（ティービーエーか）とは、油脂の変質の指標となる数値のひとつ。 (ja)
- As substâncias reativas ao ácido tiobarbitúrico - TBARS (do inglês: Thiobarbituric acid reactive substances) - são formadas como um subproduto da peroxidação lipídica (isto é, como produtos de degradação de gorduras) que podem ser detectadas pelo ensaio TBARS usando ácido tiobarbitúrico como um reagente. Devido ao fato que as espécies reativas de oxigênio têm meia-vida extremamente curta, elas são difíceis de medir diretamente. Em vez disso, o que pode ser medido são os vários produtos dos danos produzidos pelo stress oxidativo, tais como as TBARS. Os ensaios de TBARS medem o malondialdeído (MDA) presente na amostra, bem como o malondialdeído gerado a partir de hidroperóxidos de lípidos pelas condições hidrolíticas da reacção. O MDA é um dos vários produtos finais de baixo peso molecular formados através da decomposição de certos produtos de peroxidação lipídica primárias e secundárias. No entanto, apenas alguns produtos da peroxidação lipídica geram o MDA, e o MDA não é nem o único produto final da formação e decomposição de peróxido graxo, nem uma substância gerada exclusivamente por meio de peroxidação lipídica. Estas e outras considerações a partir da extensa literatura sobre MDA, reatividade TBA, e a degradação de lipídios oxidativos apoiar a conclusão de que a determinação MDA e o teste de TBA podem oferecer, na melhor das hipóteses, uma janela estreita e um pouco empírica sobre o complexo processo de peroxidação lipídica. O uso da análise do MDA e/ou o teste de TBA e interpretação de amostra de conteúdo MDA, e resposta do teste TBA em estudos de peroxidação lipídica exigem cautela, discrição e (especialmente em sistemas biológicos) dados correlatos de outros índices de formação de peróxido graxo e decomposição. Outro método de determinar o stress oxidativo é medir o desaparecimento de antioxidantes, tais como o alfa-tocoferol, a partir do sangue. Uma vez que a maioria dos, tocoferóis do plasma, são encontrados em lipidos do plasma, que se mostrou diminuir em doentes em estado crítico, qualquer medida de tocoferóis do plasma na população gravemente doente deve ser indexado ao colesterol total. (pt)
|
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)