About: Synaptic gating

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Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).

Attributes	Values
rdf:type	disease
rdfs:label	Synaptic gating (en)
rdfs:comment	Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation). (en)
foaf:depiction
dcterms:subject	Neurophysiology
Wikipage page ID	9916386 (xsd:integer)
Wikipage revision ID	1087532387 (xsd:integer)
Link from a Wikipage to another Wikipage	Electronic circuit Entorhinal cortex Neural network Mesolimbic pathway Depolarization Neurophysiology Amygdala Child Behavior Checklist Gate control theory Neuron GABA Selective attention Synapse Action potential ADHD Basal ganglia Nucleus accumbens Prefrontal cortex Hyperpolarization (biology) AMPA receptor AND gate Summation Threshold potential Transistor dbr:Dopamine Auditory cortex Positive reinforcer Methylphenidate Cerebral cortex Ventral tegmental area Shunting inhibition Excitatory postsynaptic potential NMDA receptor Thalamus Medial prefrontal cortex Resting membrane potential Neuromodulation (biology)
sameAs	Synaptic gating Synaptic gating Synaptic gating
dbp:wikiPageUsesTemplate	dbt:Main dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/Gatekeeping.png?width=300
has abstract	Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation). Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia. (en)
gold:hypernym	Ability
prov:wasDerivedFrom	wikipedia-en:Synaptic_gating?oldid=1087532387&ns=0
page length (characters) of wiki page	24763 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Synaptic_gating
is Link from a Wikipage to another Wikipage of	Gating (electrophysiology) Gatekeeper (disambiguation) Gating
is Wikipage disambiguates of	Gating
is foaf:primaryTopic of	wikipedia-en:Synaptic_gating

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