Southern Illinois, also known as Little Egypt, is the southern third of Illinois, principally along and south of Interstate 64. Although part of a Midwestern state, this region is aligned in culture more with that of the Upland South than the Midwest. Part of downstate Illinois, it is bordered by the two most voluminous rivers in the United States: the Mississippi below its connecting Missouri River to the west and the Ohio River to the east and south with the Wabash as tributary.