About: Small nucleolar RNA U3     Goto   Sponge   NotDistinct   Permalink

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In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing.

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rdfs:label
  • Small nucleolar RNA U3 (en)
rdfs:comment
  • In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing. (en)
name
  • U3 (en)
  • Small nucleolar RNA U3 (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Metazoan_U3_secondary_structure.png
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Tax domain
  • Eukaryota; (en)
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thumbnail
OMIM
AltSymbols
  • RNU3P2, (en)
caption
  • Metazoan U3 RNA secondary structure and sequence conservation (en)
id
  • RF00012 (en)
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  • U3 (en)
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  • In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing. The box C/D element is a subset of the six short sequence elements found in all U3 snoRNAs, namely boxes A, A', B, C, C', and D. The U3 snoRNA secondary structure is characterized by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hyper-methylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA. (en)
EntrezGene
HGNCid
Rfam
  • RF00012 (en)
RNA type
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