About: Single cell sequencing

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Single-cell sequencing examines the sequence information from individual cells with optimized next-generation sequencing technologies, providing a higher resolution of cellular differences and a better understanding of the function of an individual cell in the context of its microenvironment. For example, in cancer, sequencing the DNA of individual cells can give information about mutations carried by small populations of cells. In development, sequencing the RNAs expressed by individual cells can give insight into the existence and behavior of different cell types. In microbial systems, a population of the same species can appear genetically clonal. Still, single-cell sequencing of RNA or epigenetic modifications can reveal cell-to-cell variability that may help populations rapidly adapt

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rdfs:label	Secuenciación de células individuales (es) Séquençage de cellule unique (fr) Single cell sequencing (en) Секвенирование ДНК одиночных клеток (ru) 单细胞测序 (zh)
rdfs:comment	Le séquençage de cellule unique est un ensemble de techniques de biologie moléculaire qui permet l'analyse de l'information génétique (ADN, ARN, épigénome, etc.) à l'échelle d'une seule cellule, grâce à l'optimisation des technologies du séquençage nouvelle génération. En comparaison des techniques de séquençage traditionnel, cette technologie permet d'étudier les différences cellulaires avec une résolution optimale et ainsi de comprendre la particularité d'une cellule au sein de son micro-environnement. (fr) 单细胞测序（英語：Single cell sequencing）采取优化的下一代DNA測序技术（NGS）检测单细胞的序列，可以获得特定微环境下的细胞序列差异以方便研究其功能差异等。对个体细胞的DNA测序可以帮助我们了解例如在癌症中的小范围细胞的变异；对其进行RNA测序可以帮助我们了解和鉴别不同的细胞类型與其表現的基因，对研究发育生物学等有较大裨益。 (zh) La secuenciación de células individuales (single-cell sequencing en inglés) es un conjunto de tecnologías utilizadas para determinar el orden de los nucleótidos en el ADN o ARN de células individuales.Debido a la posibilidad de estudiar a cada célula por separado, estas tecnologías poseen una resolución superior a los métodos de secuenciación tradicionales (basados en el estudio de tejidos completos) y, en consecuencia, tienen muchas aplicaciones en la biología celular y la biomedicina. Por ejemplo, la secuenciación de células individuales se ha utilizado para entender la composición de diversos órganos o tejidos y descubrir nuevos tipos celulares. Igualmente, en el campo de la biología del desarrollo estas tecnologías permiten estudiar a detalle los procesos de diferenciación celul (es) Single-cell sequencing examines the sequence information from individual cells with optimized next-generation sequencing technologies, providing a higher resolution of cellular differences and a better understanding of the function of an individual cell in the context of its microenvironment. For example, in cancer, sequencing the DNA of individual cells can give information about mutations carried by small populations of cells. In development, sequencing the RNAs expressed by individual cells can give insight into the existence and behavior of different cell types. In microbial systems, a population of the same species can appear genetically clonal. Still, single-cell sequencing of RNA or epigenetic modifications can reveal cell-to-cell variability that may help populations rapidly adapt (en) Секвени́рование ДНК одино́чных кле́ток (англ. Single-cell DNA sequencing) — подход, позволяющий получить данные о последовательности ДНК отдельной клетки с помощью секвенирования и, следовательно, выявлять различия между отдельными клетками одноклеточных организмов, органов, тканей и клеточных субпопуляций многоклеточных организмов. Подход позволяет анализировать функциональные особенности клетки в контексте микроокружения. Секвенирование генома единичной клетки включает несколько шагов: выделение одной клетки, полногеномная амплификация, создание библиотек и секвенирование ДНК с использованием методов секвенирования нового поколения. (ru)
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dcterms:subject	Biotechnology DNA sequencing Molecular biology techniques
Wikipage page ID	42067613 (xsd:integer)
Wikipage revision ID	1116797572 (xsd:integer)
Link from a Wikipage to another Wikipage	Caenorhabditis elegans Mosaic (genetics) MALBAC Patch-sequencing Processivity SPAdes Allele DNA methylation Developmental biology Library (biology) Biotechnology Gene co-expression network Gene expression profiling Genome sequence Copy number variation Machine learning Cluster analysis Zebrafish Transposable element Microarray Microfluidics dbr:Bromodeoxyuridine Cell (biology) Whole genome sequencing Ion semiconductor sequencing Single-cell DNA template strand sequencing RNA-Seq Reduced representation bisulfite sequencing 5-Hydroxymethylcytosine 5-Methylcytosine Ambystoma mexicanum DNA sequencing Molecular biology techniques DNA sequencing Fluorescence-activated cell sorting Breakage-fusion-bridge cycle Breakthrough of the Year Pan-Cancer Analysis Chromothripsis Bioinformatic Gold standard (test) Rolling circle replication Haplotype Bisulfite sequencing Coefficient of variation Poisson distribution Human genome Immunology Infection Microbiome Oncology Orders of magnitude (mass) Xenopus laevis Microgram Mobile genetic elements Multiple displacement amplification Single-nucleotide polymorphism Science Magazine Single cell epigenomics Unique molecular identifier Neurology Schmidtea mediterranea Illumina dye sequencing List of single cell omics methods Nanopore sequencing Polyadenylation Single-cell analysis Single-cell transcriptomics Sanger sequencing Next generation sequencing RNA-seq Structural variation Reverse transcription Polymerases Fluorescent in situ hybridization Illumina sequencing Single-nucleotide polymorphisms Laser-capture microdissection dbr:File:Single_Cell_Genome_Sequencing_Workflow.pdf dbr:MGI_dye_sequencing dbr:File:RNA-Seq_workflow-5.pdf

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