Sereno Elmer Brett (October 31, 1891 – September 9, 1952) was a highly decorated brigadier general in the United States Army who fought in both World War I and World War II and played a key, if little recognized today, role in the development of armored warfare along with the creation of the U.S. Interstate Highway. He was also a lifelong friend of U.S. President, and former army colleague, Dwight D. Eisenhower.