About: Sarizotan

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An Entity of Type : yago:WikicatPyridines, within Data Space : dbpedia.org associated with source document(s)
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http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FSarizotan

Sarizotan (EMD-128,130) is a selective 5-HT1A receptor agonist and D2 receptor antagonist, which has antipsychotic effects, and has also shown efficacy in reducing dyskinesias resulting from long-term anti-Parkinsonian treatment with levodopa.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Pill (pharmacy) yago:WikicatAmines yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Base114618253 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MethaneSeries114951377 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Pyridine114692510 yago:Relation100031921 drug yago:Statement106722453 yago:Substance100019613 yago:WikicatPyridines
rdfs:label	Sarizotan (en)
rdfs:comment	Sarizotan (EMD-128,130) is a selective 5-HT1A receptor agonist and D2 receptor antagonist, which has antipsychotic effects, and has also shown efficacy in reducing dyskinesias resulting from long-term anti-Parkinsonian treatment with levodopa. (en)
foaf:depiction
dcterms:subject	Abandoned drugs Amines Fluoroarenes Secondary amines 5-HT1A agonists 5-HT7 agonists D2 antagonists Pyridines Chromanes
Wikipage page ID	26637162 (xsd:integer)
Wikipage revision ID	1094076117 (xsd:integer)
Link from a Wikipage to another Wikipage	Robalzotan Dopamine receptor D2 Dyskinesia Abandoned drugs Amines Fluoroarenes Secondary amines Antipsychotic 5-HT1A agonists 5-HT7 agonists Agonist 5-HT1A receptor D2 antagonists Osemozotan Parkinson's disease Pyridines Chromanes Binding selectivity Piclozotan Merck KGaA Levodopa Antagonist (pharmacology)
sameAs	Sarizotan Sarizotan Sarizotan Sarizotan Sarizotan Sarizotan
dbp:wikiPageUsesTemplate	dbt:Antipsychotics dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Reflist dbt:Serotonin_receptor_modulators dbt:Short_description dbt:Fdacite dbt:Antiparkinsonian dbt:Dopamine_receptor_modulators
thumbnail	wiki-commons:Special:FilePath/Sarizotan_Structure.svg?width=300
ATC prefix	none (en)
c	22 (xsd:integer)
CAS number	351862 (xsd:integer)
ChemSpiderID	2319847 (xsd:integer)
F	1 (xsd:integer)
H	21 (xsd:integer)
IUPAC name	1 (xsd:integer)
legal status	Discontinued (en)
n	2 (xsd:integer)
O	1 (xsd:integer)
pregnancy category	N/A (en)
PubChem	6918388 (xsd:integer)
routes of administration	Oral (en)
SMILES	C1CC2=CC=CC=C2O[C@H]1CNCC3=CN=CCC4=CC=CF (en)
UNII	467 (xsd:integer)
has abstract	Sarizotan (EMD-128,130) is a selective 5-HT1A receptor agonist and D2 receptor antagonist, which has antipsychotic effects, and has also shown efficacy in reducing dyskinesias resulting from long-term anti-Parkinsonian treatment with levodopa. In June 2006, the developer Merck KGaA announced that the development of sarizotan was discontinued, after two sarizotan Phase III studies (PADDY I, PADDY II) failed to meet the primary efficacy endpoint and neither the Phase II findings nor the results from preclinical studies could be confirmed. No statistically significant difference of the primary target variable between sarizotan and placebo could be demonstrated. (en)
gold:hypernym	HT
prov:wasDerivedFrom	wikipedia-en:Sarizotan?oldid=1094076117&ns=0
page length (characters) of wiki page	5592 (xsd:nonNegativeInteger)
CAS number	351862-32-3

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