Santiago Donovan Guzmán (born July 25, 1949) is a retired Dominican professional baseball player, a right-handed pitcher who appeared in 12 Major League games for the St. Louis Cardinals from 1969–1972. The native of San Pedro de Macorís stood 6 feet 2 inches (1.88 m) tall and weighed 180 pounds (82 kg). He retired after the 1973 season. All told, Santiago Guzmán allowed 30 hits and 18 bases on balls in 32 innings of work with the Cardinals. He struck out 29.