S-specific spore photoproduct lyase (EC 4.1.99.15, SAM, SP lyase, SPL, SplB, SplG) is an enzyme with systematic name S-specific spore photoproduct pyrimidine-lyase. This enzyme catalyses the following chemical reaction (5S)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in DNA) + S-adenosyl-L-methionine thymidylyl-(3'->5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine This enzyme is an iron-sulfur protein.
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