Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. Russell bodies are eosinophilic, homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum. Russell bodies are large and globular of varying size, and become packed into the cell's cytoplasm pushing the nucleus to the edge of the cell, and are found in the peripheral areas of tumors. Russell bodies are thought to have originated as abnormal proteins that have not been secreted. The excess immunoglobulin builds up and forms intracytoplasmic globules, which is thought to be a result of insufficient protein transport within the cell. This causes the proteins
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| - Cuerpos de Russell (es)
- Corpuscoli di Russell (it)
- ラッセル小体 (ja)
- Russell bodies (en)
- Corpúsculo de Russel (pt)
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| - Los cuerpos de Russell son grandes inclusiones homogéneas, de aspecto redondeados y eosinofílicas producidas por la acumulación de inmunoglobulinas recién sintetizadas, en el retículo endoplasmático rugoso de algunas células plasmáticas.Es un tipo celular encontrado en el mieloma múltiple. (es)
- I corpuscoli di Russell sono inclusioni citoplasmatiche globulari acidofile, costituite da aggregazioni di immunoglobuline, visibili al microscopio elettronico nelle plasmacellule. Sono indice di massiccia produzione di immunoglobuline. Sono a stretto contatto con il reticolo endoplasmatico ruvido e assumono una colorazione PAS positiva. Si tratta di una delle alterazioni cellulari presenti nel mieloma multiplo. (it)
- ラッセル小体（英: Russell body）は、一般に免疫グロブリンの過剰産生を経た形質細胞で観察される均一の免疫グロブリンを有する巨大な好酸性の構造物。ラッセル小体は腫大した小胞体を特徴とする。 多発性骨髄腫で観察される細胞変化の1つ。 ラッセル小体の名称は、スコットランドの内科医ウィリアム・ラッセルにちなむ。 米国アムジェン社を中心に、生産効率の高い抗体医薬品候補のクローンを発見する際の細胞のphenotypeスクリーニングなど、バイオテクノロジーの分野での応用にも注目されている。 (ja)
- Corpúsculo de Russel é o acúmulo excessivo de proteínas (imunoglobulinas) em plasmócitos, sendo frequentes em algumas inflamações agudas ou crônicas ou em indivíduos recém vacinados. Ele possui caráter eosinófilo. (pt)
- Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. Russell bodies are eosinophilic, homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum. Russell bodies are large and globular of varying size, and become packed into the cell's cytoplasm pushing the nucleus to the edge of the cell, and are found in the peripheral areas of tumors. Russell bodies are thought to have originated as abnormal proteins that have not been secreted. The excess immunoglobulin builds up and forms intracytoplasmic globules, which is thought to be a result of insufficient protein transport within the cell. This causes the proteins (en)
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| - Los cuerpos de Russell son grandes inclusiones homogéneas, de aspecto redondeados y eosinofílicas producidas por la acumulación de inmunoglobulinas recién sintetizadas, en el retículo endoplasmático rugoso de algunas células plasmáticas.Es un tipo celular encontrado en el mieloma múltiple. (es)
- Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. Russell bodies are eosinophilic, homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum. Russell bodies are large and globular of varying size, and become packed into the cell's cytoplasm pushing the nucleus to the edge of the cell, and are found in the peripheral areas of tumors. Russell bodies are thought to have originated as abnormal proteins that have not been secreted. The excess immunoglobulin builds up and forms intracytoplasmic globules, which is thought to be a result of insufficient protein transport within the cell. This causes the proteins to neither be degraded or secreted and stay stored in dilated cisternae. In 1949, Pearse discovered that Russell bodies also contain mucoproteins that are secreted by plasma cells. Russell bodies are not tissue specific; during research they were induced in rat glioma cells. Russell bodies were found to have positive reactions to PAS stain, CD 38 and CD 138 stains. Plasma cells that contain Russell bodies and are stained with H&E stain are found to be autofluorescent, while those without Russell bodies are not. Russell bodies tend to be found in places with chronic inflammation. This is one cell variation found in multiple myeloma. Similar inclusion bodies that tend to overlie the nucleus or invaginate into it are known as Dutcher bodies. They are named for William Russell (1852-1940), a Scottish physician. (en)
- I corpuscoli di Russell sono inclusioni citoplasmatiche globulari acidofile, costituite da aggregazioni di immunoglobuline, visibili al microscopio elettronico nelle plasmacellule. Sono indice di massiccia produzione di immunoglobuline. Sono a stretto contatto con il reticolo endoplasmatico ruvido e assumono una colorazione PAS positiva. Si tratta di una delle alterazioni cellulari presenti nel mieloma multiplo. (it)
- ラッセル小体（英: Russell body）は、一般に免疫グロブリンの過剰産生を経た形質細胞で観察される均一の免疫グロブリンを有する巨大な好酸性の構造物。ラッセル小体は腫大した小胞体を特徴とする。 多発性骨髄腫で観察される細胞変化の1つ。 ラッセル小体の名称は、スコットランドの内科医ウィリアム・ラッセルにちなむ。 米国アムジェン社を中心に、生産効率の高い抗体医薬品候補のクローンを発見する際の細胞のphenotypeスクリーニングなど、バイオテクノロジーの分野での応用にも注目されている。 (ja)
- Corpúsculo de Russel é o acúmulo excessivo de proteínas (imunoglobulinas) em plasmócitos, sendo frequentes em algumas inflamações agudas ou crônicas ou em indivíduos recém vacinados. Ele possui caráter eosinófilo. (pt)
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