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About: RhoGEF domain     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinDomains, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Attribute100024264yago:Chemical114806838yago:Compound114818238yago:Environment113934596yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921proteinyago:Situation113927383yago:Sphere114514039yago:State100024720yago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatPeripheralMembraneProteinsyago:WikicatProteinDomains New Facet based on Instances of this Class

RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42. The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.