Retroprogesterone, also known as 9β,10α-progesterone or as 9β,10α-pregn-4-ene-3,20-dione, is a progestin which was never marketed. It is a stereoisomer of the naturally occurring progestogen progesterone, in which the hydrogen atom at the 9th carbon is in the α-position (below the plane) instead of the β-position (above the plane) and the methyl group at the 10th carbon is in the β-position instead of the α-position. In other words, the atom positions at the two carbons have been reversed relative to progesterone, hence the name retroprogesterone. This reversal results in a "bent" configuration in which the plane of rings A and B is orientated at a 60° angle below the rings C and D. This configuration is ideal for interaction with the progesterone receptor, with retroprogesterone binding w
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| - Retroprogesterone (en)
- 逆孕酮 (zh)
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| - 逆孕酮（英語：Retroprogesterone，也被称为9β,10α-孕酮，9β,10α-progesterone，或9β,10α-孕-4-烯-3,20-二酮，9β,10α-pregn-4-ene-3,20-dione）是一种黄体制剂但从未上市。它是天然孕酮的立体异构体，在其B环上的9号碳原子的氢原子位于β-位（高出平面）而非孕酮的α-位（低于平面），同时10号碳原子上的甲基基团为α-位而非孕酮的β-位。换句话说，就是9、10两个碳原子的空间结构与孕酮相反，因此得名“逆”（retro）孕酮。这种逆转导致甾环骨架的弯曲结构，使得A环和B环的平面在C环和D环下方，呈60°角。。这种结构非常适合与孕酮受体相互作用，因此逆孕酮比孕酮有着更高的受体亲和力。同时，这一结构不适合与其他结合，因此逆孕酮及其衍生物也具有更高的对于孕酮受体的选择性。 逆孕酮是多种黄体制剂的，包括已上市的地屈孕酮（6-脱氢逆孕酮）和群孕酮 (1,6-双脱氢-6-氯逆孕酮）和从未上市的，以及这些黄体制剂的一些活性代謝產物。 (zh)
- Retroprogesterone, also known as 9β,10α-progesterone or as 9β,10α-pregn-4-ene-3,20-dione, is a progestin which was never marketed. It is a stereoisomer of the naturally occurring progestogen progesterone, in which the hydrogen atom at the 9th carbon is in the α-position (below the plane) instead of the β-position (above the plane) and the methyl group at the 10th carbon is in the β-position instead of the α-position. In other words, the atom positions at the two carbons have been reversed relative to progesterone, hence the name retroprogesterone. This reversal results in a "bent" configuration in which the plane of rings A and B is orientated at a 60° angle below the rings C and D. This configuration is ideal for interaction with the progesterone receptor, with retroprogesterone binding w (en)
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| - Retroprogesterone, also known as 9β,10α-progesterone or as 9β,10α-pregn-4-ene-3,20-dione, is a progestin which was never marketed. It is a stereoisomer of the naturally occurring progestogen progesterone, in which the hydrogen atom at the 9th carbon is in the α-position (below the plane) instead of the β-position (above the plane) and the methyl group at the 10th carbon is in the β-position instead of the α-position. In other words, the atom positions at the two carbons have been reversed relative to progesterone, hence the name retroprogesterone. This reversal results in a "bent" configuration in which the plane of rings A and B is orientated at a 60° angle below the rings C and D. This configuration is ideal for interaction with the progesterone receptor, with retroprogesterone binding with high affinity to this receptor. However, the configuration is not as ideal for binding to other steroid hormone receptors, and as a result, retroprogesterone derivatives have increased selectivity for the progesterone receptor relative to progesterone. Retroprogesterone is the parent compound of a group of progestins consisting of the marketed progestins dydrogesterone (6-dehydroretroprogesterone) and trengestone (1,6-didehydro-6-chlororetroprogesterone) and the never-marketed progestin Ro 6-3129, as well as the active metabolites of these progestins like 20α-dihydrodydrogesterone and 20α-dihydrotrengestone (i.e., the 20α-hydroxylated analogues). (en)
- 逆孕酮（英語：Retroprogesterone，也被称为9β,10α-孕酮，9β,10α-progesterone，或9β,10α-孕-4-烯-3,20-二酮，9β,10α-pregn-4-ene-3,20-dione）是一种黄体制剂但从未上市。它是天然孕酮的立体异构体，在其B环上的9号碳原子的氢原子位于β-位（高出平面）而非孕酮的α-位（低于平面），同时10号碳原子上的甲基基团为α-位而非孕酮的β-位。换句话说，就是9、10两个碳原子的空间结构与孕酮相反，因此得名“逆”（retro）孕酮。这种逆转导致甾环骨架的弯曲结构，使得A环和B环的平面在C环和D环下方，呈60°角。。这种结构非常适合与孕酮受体相互作用，因此逆孕酮比孕酮有着更高的受体亲和力。同时，这一结构不适合与其他结合，因此逆孕酮及其衍生物也具有更高的对于孕酮受体的选择性。 逆孕酮是多种黄体制剂的，包括已上市的地屈孕酮（6-脱氢逆孕酮）和群孕酮 (1,6-双脱氢-6-氯逆孕酮）和从未上市的，以及这些黄体制剂的一些活性代謝產物。 (zh)
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