About: Retinal degeneration (rhodopsin mutation)

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Retinal degeneration is a retinopathy which consists in the deterioration of the retina caused by the progressive death of its cells. There are several reasons for retinal degeneration, including artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. (retrolental fibroplasia/ retinopathy of prematurity), or disease (usually hereditary). These may present in many different ways such as impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision. Of the retinal degenerative diseases retinitis pigmentosa (RP) is a very important example.

Attributes	Values
rdf:type	disease
rdfs:label	Retinal degeneration (rhodopsin mutation) (en)
rdfs:comment	Retinal degeneration is a retinopathy which consists in the deterioration of the retina caused by the progressive death of its cells. There are several reasons for retinal degeneration, including artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. (retrolental fibroplasia/ retinopathy of prematurity), or disease (usually hereditary). These may present in many different ways such as impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision. Of the retinal degenerative diseases retinitis pigmentosa (RP) is a very important example. (en)
foaf:depiction
dcterms:subject	Eye diseases
Wikipage page ID	22671435 (xsd:integer)
Wikipage revision ID	1110397595 (xsd:integer)
Link from a Wikipage to another Wikipage	Proline Rod cells Endocytosis Hereditary Blindness Retina Retinopathy of prematurity United States Visual acuity Visual perception Intron Electrophysiological G protein-coupled receptors Cone cells Genetics Peripheral vision Gene Mutations Opsin Apoptosis Photoreceptor cell Macular degeneration Transgenic Autosomal dominant Codon Cytoplasmic Locus (genetics) Peripherin Alleles Amino acid Night blindness Overexpression Ribosomal frameshift Kinase Retinal detachment Visual field Prognosis Histidine Phenotypic heterogeneity Rhodopsin Arrestin Eye diseases Biosynthesis Truncation Tunnel vision Diabetic retinopathy C-terminus Neurons Retinitis pigmentosa Rod cell Missense mutations Retinopathy PRPF31 Spliceosome Point mutations Neurodegenerative Transgenic animals Transmembrane Phototransduction Retrolental fibroplasia Wild-type Neurodegenerative disorder Splice site dbr:Wikt:spicule
sameAs	Retinal degeneration (rhodopsin mutation) Retinal degeneration (rhodopsin mutation) Retinal degeneration (rhodopsin mutation)
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thumbnail	wiki-commons:Special:FilePath/Fundi_of_patient_with_Refsum_disease.jpg?width=300
has abstract	Retinal degeneration is a retinopathy which consists in the deterioration of the retina caused by the progressive death of its cells. There are several reasons for retinal degeneration, including artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. (retrolental fibroplasia/ retinopathy of prematurity), or disease (usually hereditary). These may present in many different ways such as impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision. Of the retinal degenerative diseases retinitis pigmentosa (RP) is a very important example. Inherited retinal degenerative disorders in humans exhibit genetic and phenotypic heterogeneity in their underlying causes and clinical outcomes. These retinopathies affect approximately one in 2000 individuals worldwide. A wide variety of causes have been attributed to retinal degeneration, such as disruption of genes that are involved in phototransduction, biosynthesis and folding of the rhodopsin molecule, and the structural support of the retina. Mutations in the rhodopsin gene account for 25% to 30% (30% to 40% according to) of all cases of autosomal dominant retinitis pigmentosa (adRP) in North America. There are many mechanisms of retinal degeneration attributed to rhodopsin mutations or mutations that involve or affect the function of rhodopsin. One mechanism of retinal degeneration is rhodopsin overexpression. Another mechanism, whereby a mutation caused a truncated rhodopsin, was found to affect rod function and increased the rate of photoreceptor degeneration. (en)
gold:hypernym	Deterioration
prov:wasDerivedFrom	wikipedia-en:Retinal_degeneration_(rhodopsin_mutation)?oldid=1110397595&ns=0
page length (characters) of wiki page	38354 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Retinal_degeneration_(rhodopsin_mutation)
is Link from a Wikipage to another Wikipage of	Blood Ties (TV series) Bestrophin 1 Erin Lavik John E. Dowling Retinal degeneration dbr:Taurine ABHD12

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