A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences can also be found at the three prime end (3') to the transcription start site. In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site. A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding microRNAs. An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operato
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| - Gen regulador (ca)
- Regulatorgen (de)
- Gen regulador (es)
- Gen Pengatur (in)
- Gene regolatore (it)
- Regulator gene (en)
- Regulatorgen (nl)
- 调节基因 (zh)
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| - Els gens reguladors són aquells gens encarregats de controlar la velocitat de síntesi dels productes d'un o de diversos gens o rutes biosintètiques. Juntament amb els gens selectors controlen el desenvolupament dels compartiments. Els gens reguladors i selectors van ser descoberts pel genetista espanyol . (ca)
- Los genes reguladores son aquellos genes encargados de controlar la velocidad de síntesis de los productos de uno o de varios genes o rutas biosintéticas. Junto con los genes selectores controlan el desarrollo de los . Los genes reguladores y selectores fueron descubiertos por el genetista español Antonio García-Bellido. (es)
- 调节基因（英語：regulator gene）是指用来控制其他基因表达的基因。调控序列用于给调节基因编码，通常在转录起始点的5′端。 在原核生物中，调节基因通常用于编码。 (zh)
- Als Regulatorgen wird in der Genetik ein Gen bezeichnet, welches die Genexpression steuert. Dazu gehören Gene für Aktivatoren oder für Repressoren. Im Gegensatz zu Regulatorgenen codieren Strukturgene für Enzyme und Strukturproteine. (de)
- A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences can also be found at the three prime end (3') to the transcription start site. In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site. A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding microRNAs. An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operato (en)
- Dalam bidang ilmu genetika, 'gen pengatur adalah sebuah gen yang berfungsi untuk meregulasi ekspresi gen yang lain. Gen pengatur dapat menyandikan protein, atau gen tersebut dapat bekerja dalam tahap RNA, seperti dalam produksi . Di dalam prokariota, gen pengatur dapat meregulasi melalui induksi maupun represi. Jalur induksi berarti ekspresi sebuah gen struktur dapat diinduksi melalui keberadaan senyawa kimia dalam lingkungan, sementara jalur represi adalah ketika ekspresi gen struktur terhambat oleh keberadaan senyawa kimia dalam kadar tertentu. (in)
- Un gene regolatore è un gene coinvolto nel controllo dell'espressione genica di uno o più altri geni. Un gene regolatore può codificare una proteina regolatrice, o può lavorare al livello di RNA, come nel caso di geni codificanti microRNA. I geni regolatori possono essere localizzati all'interno di operoni, adiacenti ad essi, o lontani da essi. Altri geni regolatori codificano . Una si lega ad un sito sulla molecola di DNA e causa un aumento nella trascrizione d'un gene vicino. Nei procarioti, un esempio ben conosciuto di è la , coinvolta nel controllo positivo dell'operone lac. (it)
- Een regulatorgen of regelgen is een gen dat betrokken is bij de controle van de genexpressie. Regulatorgenen kunnen in een operon liggen, tegen een operon aan of ver weg van een operon. Een regulatorgen kan coderen voor een regulatoreiwit of werken op RNA-niveau, zoals bij de genen die coderen voor microRNA's. Een regulatorgen kan ook coderen voor een inactieve repressor, dat eerst bij aanwezigheid van een bepaalde stof actief wordt, zoals bij het . Bij de genregulatie spelen zowel activators als repressors een belangrijke rol. (nl)
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| - Els gens reguladors són aquells gens encarregats de controlar la velocitat de síntesi dels productes d'un o de diversos gens o rutes biosintètiques. Juntament amb els gens selectors controlen el desenvolupament dels compartiments. Els gens reguladors i selectors van ser descoberts pel genetista espanyol . (ca)
- Als Regulatorgen wird in der Genetik ein Gen bezeichnet, welches die Genexpression steuert. Dazu gehören Gene für Aktivatoren oder für Repressoren. Im Gegensatz zu Regulatorgenen codieren Strukturgene für Enzyme und Strukturproteine. Ein Regulatorgen codiert entweder für einen aktiven Repressor, der erst bei Anwesenheit eines bestimmten Substrats (Induktor) inaktiv wird, wie z. B. beim Lactose-Operon, oder es codiert für einen inaktiven Repressor, der erst bei Anwesenheit eines bestimmten Produkts aktiv wird, wie z. B. beim Tryptophan-Operon. Ein Beispiel für einen Aktivator ist das Catabolite Activator Protein bei der Katabolitrepression. (de)
- Los genes reguladores son aquellos genes encargados de controlar la velocidad de síntesis de los productos de uno o de varios genes o rutas biosintéticas. Junto con los genes selectores controlan el desarrollo de los . Los genes reguladores y selectores fueron descubiertos por el genetista español Antonio García-Bellido. (es)
- A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences can also be found at the three prime end (3') to the transcription start site. In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site. A regulator gene may encode a protein, or it may work at the level of RNA, as in the case of genes encoding microRNAs. An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operator (a gene which binds repressor proteins thus inhibiting the translation of RNA to protein via RNA polymerase). In prokaryotes, regulator genes often code for repressor proteins. Repressor proteins bind to operators or promoters, preventing RNA polymerase from transcribing RNA. They are usually constantly expressed so the cell always has a supply of repressor molecules on hand. Inducers cause repressor proteins to change shape or otherwise become unable to bind DNA, allowing RNA polymerase to continue transcription. Regulator genes can be located within an operon, adjacent to it, or far away from it. Other regulatory genes code for activator proteins. An activator binds to a site on the DNA molecule and causes an increase in transcription of a nearby gene. In prokaryotes, a well-known activator protein is the catabolite activator protein (CAP), involved in positive control of the lac operon. In the regulation of gene expression, studied in evolutionary developmental biology (evo-devo), both activators and repressors play important roles. Regulatory genes can also be described as positive or negative regulators, based on the environmental conditions that surround the cell. Positive regulators are regulatory elements that permit RNA polymerase binding to the promoter region, thus allowing transcription to occur. In terms of the lac operon, the positive regulator would be the CRP-cAMP complex that must be bound close to the site of the start of transcription of the lac genes. The binding of this positive regulator allows RNA polymerase to bind successfully to the promoter of the lac gene sequence which advances the transcription of lac genes; lac Z, lac Y, and lac A. Negative regulators are regulatory elements which obstruct the binding of RNA polymerase to the promoter region, thus repressing transcription. In terms of the lac operon, the negative regulator would be the lac repressor which binds to the promoter in the same site that RNA polymerase normally binds. The binding of the lac repressor to RNA polymerase's binding site inhibits the transcription of the lac genes. Only when a corepressor is bound to the lac repressor will the binding site be free for RNA polymerase to carry out transcription of the lac genes. (en)
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