The R45 is a provincial route in Western Cape, South Africa that connects Saldanha with Villiersdorp via Vredenburg, Malmesbury and Paarl. The route is mostly a two-lane wide-shouldered highway, however sections within Paarl and between Vredenburg and Saldanha are dual-carriageways. The R45 is co-signed with the N7 for a short segment north of Malmesbury.