Puerto Rico Highway 133 (PR-133) is a major access road in Ponce, Puerto Rico. The road is 1.2 miles long and consists of three segments called (moving eastward) "Calle Comercio" (a.k.a. "Calle Francisco Parra Duperón"), "Avenida Cuatro Calles", and "Avenida Ednita Nazario". The road has both of its endpoints, as well as its entire length, within the Ponce city limits. It runs west to east. The road is a main access road from downtown Ponce to PR-1, providing access to Guayama and all other points in the eastern portion of the Puerto Rico, and to PR-52, which provides expressway access to San Juan.