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Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function. Proteins can be designed from scratch (de novo design) or by making calculated variants of a known protein structure and its sequence (termed protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures. These predicted sequences can then be validated experimentally through methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis.

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  • تصميم البروتين
  • Disseny de proteïnes
  • Proteindesign
  • Protein design
  • Progettazione di proteine
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  • El disseny de proteïnes és el disseny de noves molècules proteiques des de zero o a partir d'una estructura coneguda. L'ús de tècniques de per a les proteïnes és una part important de l'. El disseny de models informàtics minimalistes de proteïnes () començà a mitjans de la dècada del 1990, igual que la modificació de l'estructura secundària de les proteïnes. El disseny de novo de proteïnes reals esdevingué possible poc després i al segle XXI s'ha convertit en un camp d'investigació productiu. S'espera que el disseny de noves proteïnes, tant grans com petites, servirà a la biomedicina i bioenginyeria.
  • Das Proteindesign, synonym Proteinoptimierung oder rationales Proteindesign, bezeichnet die gezielte Anpassung der Eigenschaften von Proteinen durch ortsspezifische Mutagenese der DNA. Sie ist neben der zufällig entstehenden gerichteten Evolution eine der beiden Strategien des Protein-Engineering.
  • تصميم البروتين هو لجزيئات بروتين جديدة ذات نشاط وسلوك ووظائف جديدة وذلك لمعرفة وظائف البروتينات وفهم أساسيات عملها. يمكن تصميم البروتينات من الصفر (تصميم من جديد) أو إنشاء متغيرات محسوبة من بنيةِ وتسلسلِ بروتينٍ معروف ويسمى ذلك (إعادة التصميم). تقوم مناهج التصميم المنطقي للبروتين بالتنبؤ بتسلسلات البروتين التي ستتطوى إلى بنى محددة، بعدها يمكن التحقق تجريبيا من هذه التسلسلات المتنبئ بها عبر طرق مثل: تخليق الببتيد، التطفر نوعي الموقع أو التخليق الاصطناعي للجينات.
  • Protein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function. Proteins can be designed from scratch (de novo design) or by making calculated variants of a known protein structure and its sequence (termed protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures. These predicted sequences can then be validated experimentally through methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis.
  • La progettazione di proteine, meglio nota come protein design, si prefigge l'obiettivo di creare nuove sequenze proteiche che abbiano delle specifiche attività. Fondamentale per la progettazione è la conoscenza della relazione tra sequenza-struttura-funzione. La progettazione razionale di proteine risale alla metà degli anni '70, sebbene gli approcci si basassero per lo più sulla composizione di sequenze e non tenevano conto di interazioni specifiche tra le catene a livello atomico.
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