Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme (EC 1.4.3.21) with the systematic name primary-amine:oxygen oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2 These enzymes are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone). There are SSAO inhibitors in development.
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| - Amina-primaria oxidasa (es)
- Amine primaire oxydase (fr)
- 一級アミンオキシダーゼ (ja)
- Primary-amine oxidase (en)
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| - Las amina-primaria oxidasas son un grupo de enzimas que oxidan , pero que tienen poca o ninguna actividad sobre las diaminas. Son enzimas de amplia especificidad y catalizan varias reacciones químicas de alta importancia biológica. (es)
- 一級アミンオキシダーゼ(primary-amine oxidase)は、次の化学反応を触媒する酸化還元酵素である。 RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2 反応式の通り、この酵素の基質はRCH2NH2とH2OとO2、生成物はRCHOとNH3とH2O2である。 組織名はprimary-amine:oxygen oxidoreductase (deaminating)で、別名にamine oxidase (ambiguous); amine oxidase (copper-containing); amine oxidase (pyridoxal containing) (incorrect); benzylamine oxidase (incorrect); CAO (ambiguous); copper amine oxidase (ambiguous); Cu-amine oxidase (ambiguous); Cu-containing amine oxidase (ambiguous); diamine oxidase (incorrect); diamino oxhydrase (incorrect); histamine deaminase (ambiguous); histamine oxidase (ambiguous); monoamine oxidase (ambiguous); plasma monoamine oxidase (ambiguous); polyamine oxidase (ambiguous); semicarbazide-sensitive amine oxidase (ambiguous); SSAO (ambiguous)がある。 (ja)
- Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme (EC 1.4.3.21) with the systematic name primary-amine:oxygen oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2 These enzymes are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone). There are SSAO inhibitors in development. (en)
- L'amine primaire oxydase est une oxydoréductase qui catalyse la réaction : R–CH2NH2 + H2O + O2 R–CHO + NH3 + H2O2. Cette enzyme est une quinoprotéine à cuivre sensible à l'inhibition par les composés carbonylés tels que ceux de la famille de la semicarbazide H2N–NH–CO–NH2. Elle est spécifique des amines primaires et agit très peu ou pas sur les diamines telles que l'histamine ainsi que sur les amines secondaires et les amines tertiaires. (fr)
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| - Primary-amine oxidase (en)
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| - Primary-amine oxidase (en)
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| - Amine oxidase dimer, Human (en)
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| - Las amina-primaria oxidasas son un grupo de enzimas que oxidan , pero que tienen poca o ninguna actividad sobre las diaminas. Son enzimas de amplia especificidad y catalizan varias reacciones químicas de alta importancia biológica. (es)
- Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme (EC 1.4.3.21) with the systematic name primary-amine:oxygen oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2 These enzymes are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone). Like monoamine oxidase (MAO), SSAO can deaminate short-chain primary amines, but is insensitive to MAO inhibitors. Semicarbazide inhibits the enzyme, in addition to other hydrazines, hydroxylamine and propargylamine. However, hydrazines are weak inhibitors and stronger inhibitors have been developed. SSAO is found in the smooth muscle of blood vessels and various other tissues. The physiological function of SSAO is not well understood. Development of blood vessels, lipolysis regulation, and detoxication are suggested. It may function as a scavenger enzyme to assist MAO. However, the oxidation process generates harmful products that may be involved in causing atherosclerosis and vascular damage in diabetes. Elevation of SSAO activity is observed in atherosclerosis, diabetes mellitus, obesity, cases and varicosities. There are SSAO inhibitors in development. (en)
- L'amine primaire oxydase est une oxydoréductase qui catalyse la réaction : R–CH2NH2 + H2O + O2 R–CHO + NH3 + H2O2. Cette enzyme est une quinoprotéine à cuivre sensible à l'inhibition par les composés carbonylés tels que ceux de la famille de la semicarbazide H2N–NH–CO–NH2. Elle est spécifique des amines primaires et agit très peu ou pas sur les diamines telles que l'histamine ainsi que sur les amines secondaires et les amines tertiaires. Initialement classée comme amine oxydase à cuivre (EC 1.4.3.6) sur la base de la nature du cofacteur, l'amine primaire oxydase (EC 1.4.3.21) en a été séparée de la diamine oxydase (EC 1.4.3.22). (fr)
- 一級アミンオキシダーゼ(primary-amine oxidase)は、次の化学反応を触媒する酸化還元酵素である。 RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2 反応式の通り、この酵素の基質はRCH2NH2とH2OとO2、生成物はRCHOとNH3とH2O2である。 組織名はprimary-amine:oxygen oxidoreductase (deaminating)で、別名にamine oxidase (ambiguous); amine oxidase (copper-containing); amine oxidase (pyridoxal containing) (incorrect); benzylamine oxidase (incorrect); CAO (ambiguous); copper amine oxidase (ambiguous); Cu-amine oxidase (ambiguous); Cu-containing amine oxidase (ambiguous); diamine oxidase (incorrect); diamino oxhydrase (incorrect); histamine deaminase (ambiguous); histamine oxidase (ambiguous); monoamine oxidase (ambiguous); plasma monoamine oxidase (ambiguous); polyamine oxidase (ambiguous); semicarbazide-sensitive amine oxidase (ambiguous); SSAO (ambiguous)がある。 (ja)
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