The Poughkeepsie–Newburgh–Middletown Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in New York's Hudson Valley, with the cities of Poughkeepsie, Newburgh, and Middletown as its principal cities. As of the 2020 census, the MSA had a population of 679,221 The area was centered on the urban area of Poughkeepsie-Newburgh. The Poughkeepsie-Newburgh-Middletown MSA is a component of the New York–Newark–Bridgeport, NY-NJ-CT-PA Combined Statistical Area, which had an estimated population of 23,582,649 as of the 2020 census.