Poile Zedek Synagogue was a historic synagogue at 145 Neilson Street in New Brunswick, Middlesex County, New Jersey. The congregation was founded in 1901 by a group of merchants in downtown New Brunswick's Hiram Market district. Originally named the Independent Sick and Death Benefit Association of New Brunswick, the congregation moved to its current location in 1905 and at some point began using the name Poile Zedek ("Workers of Righteousness"). The cornerstone ceremony was held for a new building on August 19, 1923, and the building was completed in 1924. The synagogue was added to the National Register of Historic Places on October 25, 1995 for its significance in architecture and religion. It is a brick building designed with Romanesque Revival style.