Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold for endodontics.
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| - Fibrina rica en plaquetas (es)
- Platelet-rich fibrin (en)
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| - La fibrina rica en plaquetas (PRF por sus siglas en inglés Platelet-Rich Fibrin), también llamada (L-PRF), o por otros autores que la llamaron Plasma Rico en Fibrina, es un segunda generación de concentrados plaquetarios autólogos. Se obtiene por medio de una técnica simple que logra una alta concentración de plaquetas, leucocitos y otras moléculas activas como citocinas y factores de crecimiento que se quedan atrapados en una matriz tridimensional de fibrina. Se utiliza para acelerar la curación de tejidos blandos y duros.También se está utilizando como un scaffold (matriz de soporte) en bioingeniería en diferentes áreas de la salud. (es)
- Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold for endodontics. (en)
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| - La fibrina rica en plaquetas (PRF por sus siglas en inglés Platelet-Rich Fibrin), también llamada (L-PRF), o por otros autores que la llamaron Plasma Rico en Fibrina, es un segunda generación de concentrados plaquetarios autólogos. Se obtiene por medio de una técnica simple que logra una alta concentración de plaquetas, leucocitos y otras moléculas activas como citocinas y factores de crecimiento que se quedan atrapados en una matriz tridimensional de fibrina. Se utiliza para acelerar la curación de tejidos blandos y duros.También se está utilizando como un scaffold (matriz de soporte) en bioingeniería en diferentes áreas de la salud. (es)
- Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold for endodontics. To obtain PRF, required quantity of blood is drawn quickly into test tubes without an anticoagulant and centrifuged immediately. Blood can be centrifuged using a tabletop centrifuge from 3-8 minutes for 1300 revolutions per minute. The resultant product consists of the following three layers; topmost layer consisting of platelet poor plasma, PRF clot in the middle, and red blood cells (RBC) at the bottom. PRF is available as a fibrin clot. PRF clot can be removed from the test tube using a sterile tweezer-like instrument. After lifting, the RBC layer attached to the PRF clot can be carefully removed using a sterilized scissor. Platelet activation in response to tissue damage occurs during the process of making PRF release several biologically active proteins including; platelet alpha granules, platelet‑derived growth factor (PGDF), transforming growth factors‑β (TGF‑β), vascular endothelial growth factor (VEGF), and epidermal growth factor. Actually, the platelets and leukocyte cytokines play important parts in role of this biomaterial, but the fibrin matrix supporting them is the most helpful in constituting the determining elements responsible for real therapeutic potential of PRF. Cytokines are immediately used and destroyed in a healing wound. The harmony between cytokines and their supporting fibrin matrix has much more importance than any other platelet derivatives. (en)
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