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Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Scramblases are not members of the general family of transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different types of enzymatic groups of phospholipid transportation enzymes. The inner-leaflet, facing the inside of the cell, contains negatively charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an en

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  • Escramblasa
  • Phospholipid scramblase
  • Scramblase
  • Scramblasi
  • Scramblase
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  • L'escramblasa, en anglès: Scramblase, és una proteïna responsable de la translocació de fosfolípids entre les dues monocapes d'una capa bilipídica de la membrana cel·lular. En els humans, les escramblases fosfolípides (PLSCRs) constitueixen una família de cinc proteïnes homòlogues que s'anomenen hPLSCR1–hPLSCR5. L'escramblasa és un enzim present en la membrana cel·lular, que poden transportar (scramble/"remenar") els fosfolípids carregats negativament des de la capa interna a la capa externa i vice versa.
  • Le scramblasi (dall'inglese "to scramble" che significa mescolare) sono proteine adibite allo spostamento dei fosfolipidi da un monostrato all'altro del doppio strato lipidico all'interno della membrana plasmatica di una cellula. Questa proteina, a differenza della flippasi non è selettiva nei confronti dei lipidi ma li "capovolge" dall'altro lato della membrana in maniera casuale e aspecifica. Essa pertanto fa sì che i fosfolipidi non vengano aggiunti solamente da un lato al momento della formazione o dell'espansione della membrana, ma anche dal lato opposto a contatto con l'ambiente extracellulare.
  • A scramblase é uma proteína responsável pela translocação de fosfolípidos entre duas monocamadas de uma bicapa lipídica da membrana celular. Em humanos, as scramblases fosfolipídicas constituem uma família de cinco proteínas homólogas denominadas hPLSCR1–hPLSCR5. As scamblases são membros da família geral de transportadores lípidicos transmembranares conhecida como . O folheto interno da membrana contém amino-fosfolípidos e fosfatidiletanolaminas carregadas negativamente. O folheto externo, contém fosfatidilcolina e .
  • Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Scramblases are not members of the general family of transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different types of enzymatic groups of phospholipid transportation enzymes. The inner-leaflet, facing the inside of the cell, contains negatively charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an en
  • Une scramblase est une protéine membranaire responsable de la translocation des phospholipides entre les deux feuillets de la bicouche lipidique d'une membrane cellulaire. Le feuillet interne de la bicouche lipidique, qui fait face au cytoplasme, contient des amino-phospholipides chargés négativement et des phosphatidyléthanolamines ; le feuillet externe, qui fait face au milieu extracellulaire, contient des phosphatidylcholines et des sphingomyélines : les scramblases favorisent l'échange des phospholipides chargés négativement entre les deux feuillets de la bicouche lipidique. Leur activité dépend de la présence d'ions calcium Ca2+.
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  • Phospholipid scramblase 1
  • Phospholipid scramblase 2
  • Phospholipid scramblase 3
  • Phospholipid scramblase 4
  • Phospholipid scramblase family, member 5
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