Pennsylvania Route 106 (PA 106) is a 20.69-mile-long (33.30 km) state highway located in both Susquehanna and Lackawanna counties in Pennsylvania. Route 106 begins at a fork from U.S. Route 11 (US 11) in the community of Kingsley. The route heads southeasterly for most of its length, interchanging with Interstate 81 (I-81) in Lenox Township. PA 106 continues into the city of Carbondale, where the designation terminates at US 6 Business (US 6 Bus., North Main Street), the former alignment of US 6 through Carbondale.