Panther Creek State Park is a state park in Morristown, Tennessee, United States. It is located prominently on the shore of Cherokee Lake, an impoundment of the Holston River. The western terminus of Tennessee State Route 342 is located inside the park. The route connects the park to U.S. Route 11E (also known as Andrew Johnson Highway). The park has an area of approximately 1,444 acres (6 km2).